Fig. 1: The p53 isoform, Δ133TP53β, is upregulated in prostate cancers.
From: The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer
Box and whisker plots show relative TP53 transcript levels in a. Non-neoplastic prostate tissues (n = 3) and in 2 prostate cancer cohorts: b cohort 1 (n = 43) and c. cohort 2 (n = 79). a–c Symbols show individual cancers; the horizontal line in the box represents median values and the outlines represent the 25th–75th percentile, whiskers show the 10–90% CI. Significant differences were determined by Mann–Whitney U test, *p < 0.05, **p < 0.01, ***p < 0.005, . n.d. not detected. Scatter plots show the correlation of relative abundance of d. ∆133TP53 vs TP53β transcripts p < 0.0001 (left panel) and ∆133TP53 vs TP53α transcripts p = 0.24 (right panel). e ∆40TP53 vs TP53α transcripts p < 0.0001 (left panel), and ∆40TP53 vs TP53β transcripts p = 0.21 (right panel), from both prostate cancer cohorts (n = 122). Spearman ρ values are shown
