Fig. 7: Electrophysiological properties of NGN2-induced neurons from OECs.
From: Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair
a A representative visual field of the patched neuron containing GFP fluorescence. b Single action potential (AP) firing of an induced neuron which was co-cultured with astrocytes for 34 days in response to injection of a suprathreshold current pulse. c Multiple AP firing elicited by repetitious depolarizing current stimuli. d Voltage-clamp traces showing fast inward current and persistent outward current on depolarization. e Tetrodotoxin (TTX)-sensitive sodium currents. The voltage-gated Na+ currents recorded from an induced neuron (left panel) and subsequently blocked by TTX (right panel)
