Fig. 3: Long-term treatment of T1D mice with rFGF21 improves endothelium-dependent relaxation of aorta. | Cell Death & Disease

Fig. 3: Long-term treatment of T1D mice with rFGF21 improves endothelium-dependent relaxation of aorta.

From: Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway

Fig. 3

a–c STZ-induced T1D mice were treated for 30 days with rFGF21 (0.5 mg/kg body weight) or buffer control; littermate db/m mice served as controls. a Random fed blood glucose (n = 8–9). b Dose-dependent relaxation of aorta to ACh (n = 7–8). c Phosphorylation level of eNOS in aortas as determined by western blot analysis (upper panel) and quantitation using ImageJ software (lower panel) (n = 3). All data are presented as mean ± SEM. *p < 0.05 vs Control; #p < 0.05 vs T1D

Back to article page