Fig. 6: MPS-1 knockdown suppressed tumor growth in vivo. | Cell Death & Disease

Fig. 6: MPS-1 knockdown suppressed tumor growth in vivo.

From: Metallopanstimulin-1 (MPS-1) mediates the promotion effect of leptin on colorectal cancer through activation of JNK/c-Jun signaling pathway

Fig. 6: MPS-1 knockdown suppressed tumor growth in vivo.

a The tumor images taken from mice in shCtrl and shMPS-1 groups. b Tumor volume was measured in shCtrl and shMPS-1 groups at the indicated time points (6, 12, 18, 24 days post-injection). c Tumor weights were measured in shCtrl and shMPS-1 groups after sacrificing mice. d The levels of MPS-1 and Ki-67 were analyzed by IHC staining (scale bar = 100 μm). f The protein expressions of MPS-1, JNK, p-JNK, c-Jun, and p-c-Jun (Ser63 and Ser73) were detected by WB in the tumors of shCtrl and shMPS-1 groups. Error bars indicate SD of three biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001

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