Fig. 1: IMD 0354 effectively inhibits OVX-induced bone loss in vivo. | Cell Death & Disease

Fig. 1: IMD 0354 effectively inhibits OVX-induced bone loss in vivo.

From: The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation

Fig. 1: IMD 0354 effectively inhibits OVX-induced bone loss in vivo.The alternative text for this image may have been generated using AI.

a The femurs of all mice were scanned with a high-resolution micro-CT. b Calculation of the microstructural indices was performed for the micro-CT data. Microstructural indices include bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular separation (Tb.Sp), trabecular number (Tb.N), and trabecular thickness (Tb.Th). c Sections of tibias were stained with H&E. d, e Sections of tibias were stained with TRAP (black arrows, TRAP-positive cells). The number of osteoclasts per field of tissue (No.Oc/B.Pm) and percentage of osteoclast surface per bone surface (Oc.S/BS%) in sections stained by TRAP. f Serum concentrations of CTX-I. Data are presented as mean ± SD (n = 5). Scale bars, 50 μm. n.s., no significance, *P < 0.05, **P < 0.01, ***P < 0.005, compared with the vehicle group

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