Fig. 3: IMD 0354 does not affect bone formation in mice with osteoporosis in vivo. | Cell Death & Disease

Fig. 3: IMD 0354 does not affect bone formation in mice with osteoporosis in vivo.

From: The emerging role of IMD 0354 on bone homeostasis by suppressing osteoclastogenesis and bone resorption, but without affecting bone formation

Fig. 3: IMD 0354 does not affect bone formation in mice with osteoporosis in vivo.The alternative text for this image may have been generated using AI.

a Immunofluorescence analysis of Runx2 in the tibia sections. Scale bar, 50 μm. b Immunohistochemical analysis of OCN in the tibia sections. Scale bar, 100 μm. c Quantification of immunofluorescence assay of Runx2 (n = 5). d Quantification of immunohistochemical assay of OCN (n = 5). e Serum concentrations of P1NP (n = 5). f Runx2, COL1a, and OCN mRNA expression levels in the forelimbs of the treated mice (n = 3). Data are presented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.005, compared with the vehicle group

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