Fig. 3: Targeting S1PR1 can regulate the STAT3-mediated signaling pathway.

a Western blot analysis of protein expression levels of S1PR1 and p-STAT3 in SW480 and HCT116 after overexpression or shRNA with S1PR1 and STAT3, respectively. b Western blot analysis of protein expression levels of STAT3 downstream genes in SW480 and HCT116 after overexpression or shRNA with S1PR1 and STAT3, respectively