Fig. 8: linc00645 knockdown suppressed tumor growth in vivo and prolonged survival. | Cell Death & Disease

Fig. 8: linc00645 knockdown suppressed tumor growth in vivo and prolonged survival.

From: RETRACTED ARTICLE: Long non-coding RNA linc00645 promotes TGF-β-induced epithelial–mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma

Fig. 8

a, c Luminescence imaging showed the BLI value of Linc00645-shRNA treated U251-luc glioma group was decreased compared with NC-shRNA group. The dynamic process of tumor proliferation was displayed with different time point (15, 25, 35, and 40 days). The line chart showed the change of tumor BLI value. b H&E-stained coronal brain sections showing representative tumor xenografts. d The level of miR-205-3p was enriched in Linc00645-shRNA intracranial graft group detected by qRT-PCR. e The expression of ZEB1 was reduced in Linc00645-shRNA intracranial graft group detected by Western blot. The protein level was displayed with bar graph. f Kaplan-Meier survival analysis indicating that mice transfected with linc00645-shRNA revealed a significantly better outcome than the sh-NC treated group. g The schematic overview of linc00645/miR-122/ZEB1 mediated EMT in glioma. Data are shown as the mean ± SD of three independent experiments. (*P < 0.05, ***P < 0.001)

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