Fig. 6: Effects of the inhibition of TLR4 during co-culture in vitro of HS-5 with MM cell lines (U266, OPM2, H929) before injection in zebrafish. | Cell Death & Disease

Fig. 6: Effects of the inhibition of TLR4 during co-culture in vitro of HS-5 with MM cell lines (U266, OPM2, H929) before injection in zebrafish.

From: TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma

Fig. 6: Effects of the inhibition of TLR4 during co-culture in vitro of HS-5 with MM cell lines (U266, OPM2, H929) before injection in zebrafish.

a Evaluation of inhibitory capacity of ed-N obtained from coculture of HS-5 pre-treated with MM cells in presence or not of TAK-242. b Evaluation of tumor xenograft was performed by tomography after 3 days. Eight animals were engrafted for every group. (c) hCD138 infiltrate was detected by using flow cytometry. a U266 + HS-5; b U266 + HS-5 pre-treated; c U266 + HS-5 pre-treated (+TAK-242). *p < 0.05; **p < 0.01

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