Fig. 3: DGBP impacts c-myc expression independent of caspases and impacts RB and c-abl expression dependent upon caspases.
From: Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
a Western blots showing c-myc with DGBP treatment and co-treatment of GGPP, Z-VAD-FMK, or MG132 in Jurkat cells. Actin is shown as a loading control. All Western blots are representative of three independent experiments. b Western blot analysis of cleaved caspase 9, retinoblastoma (RB1), and c-abl. Tubulin is shown as a loading control. Jurkat cells were treated for 72 h with DGBP in the presence or absence of GGPP or Z-VAD-FMK. Western blots are representative of three independent experiments
