Fig. 7: DAPT and Ku55933 restore the DGBP-induced depletion of Notch1 mRNA via decreased mRNA degradation.
From: Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
a Notch1 mRNA expression relative to 18S rRNA. Jurkat cells were treated with inhibitor alone or combinations for 72 h. b Luciferase activity in Jurkat cells transfected with Notch1 3′UTR. Cells were treated with inhibitor alone or co-treated with DGBP for 72 h. In all graphs, the bars represent means and standard deviations of three independent experiments (n = 3). Statistical significance was determined by two-way ANOVA with Tukey’s post hoc analysis. *p < 0.05 versus the corresponding control. ‡p < 0.05 versus DGBP-treated condition
