Fig. 4: TRIM71 inhibits mutant p53 target gene expression in ovarian cancer.
From: Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53
a, b The expression of mtp53s and their target genes was assessed by RT-qPCR upon ectopic expression of TRIM71 in ES-2 and OVCA420 cells. Data are represented as mean ± SD, n = 3. *p < 0.05, **p < 0.01 by two tailed t test. c–j The inverse correlation between expression of TRIM71 and mtp53 target genes involved in a wide range of biological outcomes, such as proliferation c, survival d, metastasis e, metabolism f, redox homeostasis g, glycolysis h, proteasome pathway i, and chemoresistance j in ovarian cancer
