Fig. 4: Ca2+ was required for BIL-induced upregulation of activity and level of VGSCs. | Cell Death & Disease

Fig. 4: Ca2+ was required for BIL-induced upregulation of activity and level of VGSCs.

From: Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Fig. 4: Ca2+ was required for BIL-induced upregulation of activity and level of VGSCs.The alternative text for this image may have been generated using AI.

a An example recording showing that neither the frequency of spontaneous firings nor the spike waveform of a MVN neuron was altered in slices preincubated in BAPTA-AM (40 μM, 30 min). b, c Statistical results showing no significant change in spike frequency, ratio of Iinward/Ioutward. d–f MISCN1A was not statistically different between control and BIL groups (d) as exemplified by the immunofluorescence staining of nuclei (blue), NeuN (green), and SCN1A (red) in control (e) and BIL groups (f). NS no statistical difference, independent-samples t test.

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