Fig. 5: Blocking exocytosis with TAT-NSF700 precluded the effects of BIL on MVN neurons. | Cell Death & Disease

Fig. 5: Blocking exocytosis with TAT-NSF700 precluded the effects of BIL on MVN neurons.

From: Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Fig. 5: Blocking exocytosis with TAT-NSF700 precluded the effects of BIL on MVN neurons.The alternative text for this image may have been generated using AI.

a–c Example recording traces (a) showing that when the slice was preincubated with TAT-NSF700 (5 μM, 30 min), a permeable thrombin-induced exocytosis inhibitor, neither the discharge frequency of MVN neuron (b) nor the ratio of Iinward/Ioutward (c) was altered by BIL (3 μM, 3 min). d–f MISCN1A was not statistically different between control and BIL groups (d) in slices pretreated with TAT-NSF700, as illustrated by the immunofluorescence images comparing staining of nuclei (blue), NeuN (green), and SCN1A (red) in control (e) and BIL group (f). NS no statistical difference, independent-samples t-test.

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