Fig. 7: Blockade of dynamin-dependent endocytosis augments the effects of BIL on the excitability of MVN neurons. | Cell Death & Disease

Fig. 7: Blockade of dynamin-dependent endocytosis augments the effects of BIL on the excitability of MVN neurons.

From: Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Fig. 7: Blockade of dynamin-dependent endocytosis augments the effects of BIL on the excitability of MVN neurons.The alternative text for this image may have been generated using AI.

a An example recording showing that preincubation of slices with dynasore (40 μM, 30 min), an inhibitor for dynamin-dependent endocytosis, increased the basal firing rate of MVN neurons and further amplified BIL-induced increase in the ratio of Iinward/Ioutward, implicating a larger sodium current. b, c Pooled data plots, summarizing the augmented increases in the firing rate and ratio of Iinward/Ioutward. *p < 0.05, ***p < 0.001, independent-samples t-test.

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