Fig. 8: Upregulation of membrane VGSCs exacerbated MVN neuronal death. | Cell Death & Disease

Fig. 8: Upregulation of membrane VGSCs exacerbated MVN neuronal death.

From: Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity

Fig. 8: Upregulation of membrane VGSCs exacerbated MVN neuronal death.The alternative text for this image may have been generated using AI.

a–c Co-application of 3 μM BIL with 50 μM Lidocaine decreased both amplitude and frequency of spontaneous firings, while 25 μM Lidocaine prevented the augmenting effect of BIL on spontaneous firings without obviously changing the ratio of Iinward/Ioutward or frequency of spontaneous firings. d Representative images of Live (Calcein-AM, Green, left panel), Dead Cell (PI, Red, middle panel), and Overlay of fluorescence labeling under different experimental conditions. e A plot summarizing the fraction of Live (Green) and Dead cells (Red) for all experiments in (d). Independent-samples t test for spike-firing analysis, one-way ANOVA with LSD post hoc test was used for the comparison of cell death rates. NS no statistical difference.

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