Fig. 8: Cx43 channels inhibition attenuated oxidative stress and inflammatory reaction via depressing ROS in vivo. | Cell Death & Disease

Fig. 8: Cx43 channels inhibition attenuated oxidative stress and inflammatory reaction via depressing ROS in vivo.

From: Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation

Fig. 8

a–d Changes in 15-F2t-Isop, MDA, H2O2, and SOD at different reperfusion time points after AOLT. Heptanol (0.1 mg/kg, 1 h before AOLT) and NAC (200 mg/kg, 1 h before AOLT) attenuated the level of 15-F2t-Isop, MDA, H2O2, and SOD at 8 h after reperfusion. n = 8, *P < 0.05 vs sham; #P < 0.05 vs the AOLT group. Vehicle control of heptanol was DMSO, which had no significant effects on the above-mentioned parameters (data not shown). e–h Changes in IL-1β, IL-6, IL-8, and TNF-α at different reperfusion time points after AOLT. Heptanol (0.1 mg/kg, 1 h before AOLT) and NAC (200 mg/kg, 1 h before AOLT) attenuated the level of IL-1β, IL-6, IL-8, and TNF-α at 8 h after reperfusion. n = 8, *P < 0.05 vs sham; #P < 0.05 vs the AOLT group. Vehicle control of heptanol was DMSO, which had no significant effects on the above-mentioned parameters (data not shown)

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