Fig. 3: P2Y12 is expressed by human CD163+ TAM of melanoma. | Cell Death & Disease

Fig. 3: P2Y12 is expressed by human CD163+ TAM of melanoma.

From: ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12

Fig. 3

a Immunohistochemical stainings of human primary as well as metastatic melanoma using anti-hsP2Y12 and anti-hsCD68 antibodies (n = 3). b In situ hybridization of primary melanoma tissue using a P2Y12-specific probe. Small red dots indicate P2Y12 mRNA (n = 3). c Sequential staining of one human melanoma section using anti-P2Y12, anti-CD68, and anti-CD163 antibodies (n = 2). d Immunofluorescent double staining of primary melanoma using anti-CD163 (red)/anti-P2Y12 (green) antibodies (n = 3). One representative picture is shown for each staining. Scale bars = 100 µm

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