Fig. 1: Matrine inhibits the proliferation of ovarian cancer cells. | Cell Death & Disease

Fig. 1: Matrine inhibits the proliferation of ovarian cancer cells.

From: Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways

Fig. 1

a A2780 and SKOV3 cells were treated with matrine ranging from 0–2.0 mg/mL for 24, 48, and 72 h, followed by MTT assay to evaluate cell growth. Data are presented as mean ± SD (*P < 0.05, **P < 0.01). b Representative images of colony formation assay showing colonies formed by A2780 and SKOV3 cells incubated with matrine from 0 to 2.0 mg/mL. Graph indicating the number of colonies formed in A2780 and SKOV3 cells with matrine treatment. Results are representative of three experiments (*P < 0.05). c Cell cycle analysis was measured by the percentage of cells in each phase in matrine-treated A2780 and SKOV3 cells. d A2780 and SKOV3 cells were incubated with matrine for 24 h. The expression levels of p21, cyclin D1 and CDK4 were measured by western blot. e Matrine reduced the phosphorylation levels of ERK1/2 and MEK1/2 in A2780 and SKOV3 cells. GAPDH was used as a loading control

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