Fig. 8: Schematic model for endothelial cell pyroptosis in Kawasaki disease. | Cell Death & Disease

Fig. 8: Schematic model for endothelial cell pyroptosis in Kawasaki disease.

From: Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

Fig. 8: Schematic model for endothelial cell pyroptosis in Kawasaki disease.

High level of serum HMGB1 interacts with its receptor RAGE, enters lysosomes, and induces Cat B (cathepsin B) activation and release from the ruptured lysosomes. This is followed by NLRP3 inflammasome activation and subsequent induction of caspase-1-dependent pyroptosis

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