Table 5 miR-3163 enhanced the antitumor effect of sorafenib on HCC cells’ intrahepatic migration
PDCs | Groups | Sorafenib | Regorafenib | Lenvatinib | Anlotinib | Apatinib |
|---|---|---|---|---|---|---|
IC50 values (mg/kg) of molecular targeting agents on HCC cells’ intrahepatic migration | ||||||
No. 1 | Control | ~2 | 1.75 ± 0.59 | 1.20 ± 0.56 | 1.83 ± 0.23 | - |
miR-3163 | 0.29 ± 0.09 | 0.38 ± 0.11 | 0.11 ± 0.07 | 0.83 ± 0.79 | 0.55 ± 0.15 | |
miR-3163 + ADAM-17Mut | 1.89 ± 0.12 | ~2 | 1.51 ± 0.77 | 1.88 ± 0.64 | 1.65 ± 0.44 | |
No. 2 | Control | 1.68 ± 0.19 | 1.20 ± 0.67 | 0.56 ± 0.06 | - | - |
miR-3163 | 0.93 ± 0.33 | 0.44 ± 0.06 | 0.24 ± 0.07 | 1.84 ± 0.54 | 1.16 ± 0.75 | |
miR-3163 + ADAM-17Mut | 1.83 ± 0.23 | 1.18 ± 0.54 | 0.72 ± 0.39 | - | - | |
No. 3 | Control | 1.96 ± 0.74 | - | 1.04 ± 0.82 | - | ~2 |
miR-3163 | 0.31 ± 0.01 | 0.98 ± 0.64 | 0.76 ± 0.20 | 1.16 ± 0.26 | 0.43 ± 0.05 | |
miR-3163 + ADAM-17Mut | 1.33 ± 0.20 | - | 0.95 ± 0.32 | - | 1.84 ± 0.15 | |
No. 4 | Control | - | - | 1.69 ± 0.64 | - | - |
miR-3163 | 0.98 ± 0.09 | 0.30 ± 0.23 | 0.73 ± 0.29 | 1.02 ± 0.28 | 1.89 ± 0.62 | |
miR-3163 + ADAM-17Mut | 1.82 ± 0.43 | - | - | - | - | |
No. 5 | Control | - | - | ~2 | - | - |
miR-3163 | 1.66 ± 0.35 | 0.85 ± 0.21 | 0.53 ± 0.05 | 1.70 ± 0.30 | ~2 | |
miR-3163 + ADAM-17Mut | - | - | - | - | - | |