Table 5 miR-3163 enhanced the antitumor effect of sorafenib on HCC cells’ intrahepatic migration

From: MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents

PDCs

Groups

Sorafenib

Regorafenib

Lenvatinib

Anlotinib

Apatinib

  

IC50 values (mg/kg) of molecular targeting agents on HCC cells’ intrahepatic migration

No. 1

Control

~2

1.75 ± 0.59

1.20 ± 0.56

1.83 ± 0.23

-

miR-3163

0.29 ± 0.09

0.38 ± 0.11

0.11 ± 0.07

0.83 ± 0.79

0.55 ± 0.15

miR-3163 + ADAM-17Mut

1.89 ± 0.12

~2

1.51 ± 0.77

1.88 ± 0.64

1.65 ± 0.44

No. 2

Control

1.68 ± 0.19

1.20 ± 0.67

0.56 ± 0.06

-

-

miR-3163

0.93 ± 0.33

0.44 ± 0.06

0.24 ± 0.07

1.84 ± 0.54

1.16 ± 0.75

miR-3163 + ADAM-17Mut

1.83 ± 0.23

1.18 ± 0.54

0.72 ± 0.39

-

-

No. 3

Control

1.96 ± 0.74

-

1.04 ± 0.82

-

~2

miR-3163

0.31 ± 0.01

0.98 ± 0.64

0.76 ± 0.20

1.16 ± 0.26

0.43 ± 0.05

miR-3163 + ADAM-17Mut

1.33 ± 0.20

-

0.95 ± 0.32

-

1.84 ± 0.15

No. 4

Control

-

-

1.69 ± 0.64

-

-

miR-3163

0.98 ± 0.09

0.30 ± 0.23

0.73 ± 0.29

1.02 ± 0.28

1.89 ± 0.62

miR-3163 + ADAM-17Mut

1.82 ± 0.43

-

-

-

-

No. 5

Control

-

-

~2

-

-

miR-3163

1.66 ± 0.35

0.85 ± 0.21

0.53 ± 0.05

1.70 ± 0.30

~2

miR-3163 + ADAM-17Mut

-

-

-

-

-

  1. PDCs patients-derived HCC cell lines