Fig. 1: 26S overexpression indicates poor prognosis in MB patients.

a Diagram of the 26S proteasome complex. The 26S proteasome is formed by two subcomplexes: 19S (regulatory complex) and 20S (core proteasome). b Expression of PSMA2 in normal brain (172) vs. human MB tumours. Kaplan–Meier survival curve based on high and low PSMA2 expression levels in MB tumours derived from Cavalli cohort with 763 patients. Tumours with high PSMA2 expression showed decreased survival (P = 0.0025). c PSMB4 in normal brain (172) vs. human MB tumours. Kaplan–Meier survival curve based on high and low PSMB4 expression levels in MB tumours derived from Cavalli cohort with 763 patients. Tumours with high PSMB4 expression showed decreased survival (P = 0.0000096). PSMB4 levels in the four different groups: Group 3, Group 4, Wingless (WNT) and Sonic Hedgehog (SHH). The data are derived from Cavalli cohort with 763 patients (**P = 0.003). d PSMC6 in normal brain (172) vs. human MB tumours. Kaplan–Meier survival curve based on high and low PSMC6 expression levels in MB tumours derived from Cavalli cohort with 763 patients. Tumours with high PSMC6 expression showed decreased survival (P = 0.0000057). PSMC6 levels in the four different groups: Group 3, Group 4, WNT and SHH. The data are derived from Cavalli cohort with 763 patients (***P = 0.0001). e PSMD13 in normal brain (172) vs. human MB tumours. Kaplan–Meier survival curve based on high and low PSMD13 expression levels in MB tumours derived from Cavalli cohort with 763 patients. Tumours with high PSMD13 expression showed decreased survival (P = 0.00088). PSMD13 levels in the four different groups: Group 3, Group 4, WNT and SHH. The data are derived from Cavalli cohort with 763 patients (**P = 0.0001). Data were acquired from the R2: Genomics Analysis and Visualization Platform (https://hgserver1.amc.nl/cgi-bin/r2/main.cgi) and significance is calculated with a one-way ANOVA between groups