Fig. 6: Anti-oxidant treatments were successful in improving endothelial functions. | Cell Death & Disease

Fig. 6: Anti-oxidant treatments were successful in improving endothelial functions.

From: Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells

Fig. 6

a Representative images of tubes formed by MELAS ECs pre-treated with 100 μM Vit. C and 100 μM Co-Q10. Quantitative analysis of several tube formation parameters showed improvements in tube formation capacity after MELAS ECs were treated with the compounds. b 100 μM Vit. C treatment was effective in reducing the number of MitoSOX+ cells in MELAS ECs. c Increasing doses of edaravone was effective in reducing MitoSOX+ cells in MELAS ECs in a dose-dependent manner. d Representative images of tubes formed by MELAS ECs treated with 100 μM and 200 μM of edaravone. Quantitative analysis of several tube formation parameters showed improvements in tube formation capacity after MELAS ECs were treated with both doses of edaravone. e MELAS ECs treated with 200 μM of edaravone effectively lowered number of monocytes adhering to MELAS ECs when monocytes adhesion assay was performed. Nuclei were stained in blue with DAPI. Scale bar = 100 μm. Error bars show SD of the mean. *p < 0.05, **p < 0.01, ***p < 0.001

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