Fig. 3: The role of CXCR7 in regulating seizure activity in the KA-induced epilepsy model in mice.
From: CXCR7 regulates epileptic seizures by controlling the synaptic activity of hippocampal granule cells
Behavioral tests: a Statistical analysis of the latency of SRSs (shRNA compared with con-shRNA, p < 0.001; shRNA/CXCR7 compared with shRNA, p = 0.003; CXCR7 compared with con-CXCR7, p = 0.018); b the number of SRSs (seizures/week) (shRNA compared with con-shRNA, p < 0.001; shRNA/CXCR7 compared with shRNA, p = 0.029; CXCR7 compared with con-CXCR7, p < 0.001), and c the proportion of Racine stage 4–5 SRSs relative to the total number of SRSs (%) (shRNA compared with con-shRNA, p < 0.001; shRNA/CXCR7 compared with shRNA, p = 0.026; CXCR7 compared with con-CXCR7, p < 0.001) (n = 6 per group). One-way ANOVA with a post hoc Bonferroni test; *p < 0.05, **p < 0.01, and ***p < 0.001
