Fig. 3: Downregulation of ASPP2 promoted tumor growth in vivo by activating mevalonate biosynthesis.
From: ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
a Representative dissected tumors from nude mice treated without (top) or with (bottom) simvastatin for 3 weeks and corresponding volume measurement, b Asterisk (*) indicates P < 0.05. c Immunohistochemical staining of tumors derived from nude mice for ASPP2, HMGCR, and HMGCS1 (magnification, ×200). ASPP2-silenced groups exhibited increased HMGCR and HMGCS-1 expression. These alterations were compromised in ASPP2-silenced groups treated with simvastatin
