Fig. 5: Expression of ASPP2 correlates negatively with HMGCR in surgical specimens of HCC.
From: ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma
a ASPP2 and HMGCR were detected by immunohistochemical staining in 80 HCC samples. Representative pictures are shown for four patients. (Scale bars: 50 μm). b Table of ASPP2 and HMGCR high and low expression according to immunohistochemistry scoring. Significant negative correlation between ASPP2 and HMGCR expression was found, Fisher’s test P < 0.05. c The strong expression of ASPP2 in nuclear in 17 HCC samples. Representative pictures of immunohistochemical staining are shown for two patients.Scale bars: 50 μm. d. Table of positive ASPP2 expression in nuclear or cytoplasm and their HMGCR expression according to the scores of immunohistochemistry staining. e Left: Overall survival (OS) and right: recurrence-free survival (RFS) rate curves of the analyzed four subgroups (ASPP2 low/HMGCR low; ASPP2 low/HMGCR high; ASPP2 high /HMGCR low; ASPP2 high/HMGCR high), (n = 80). Kaplan-Meier analysis showed RFS (P < 0.05) and OS (P < 0.05) were significantly best among patients with ASPP2-high and HMGCR-low expression
