Fig. 2: Induction of Cav-1 in PCa carrying p53 and Rb mutation correlates with CSC and NED-related gene expression. | Cell Death & Disease

Fig. 2: Induction of Cav-1 in PCa carrying p53 and Rb mutation correlates with CSC and NED-related gene expression.

From: The paracrine induction of prostate cancer progression by caveolin-1

Fig. 2: Induction of Cav-1 in PCa carrying p53 and Rb mutation correlates with CSC and NED-related gene expression.

The expression profile of a Cav-1 in mRNA and protein expression level, b Yamanaka factors (OCT4, KLF4, SOX2, CMYC), and c NED-related genes (PROX1, BRN2, CGA, NSE, SYP) were determined in LNCaP Con vs. LNCAP (p53−, Rb−) by qRT-PCR. The gene expression profile of d Cav-1, e Yamanaka factors genes (OCT4, KLF4, SOX2, CMYC), and f NED-related genes (PROX1, BRN2, CGA, NSE, SYP) were determined by qRT-PCR in LNCaP (p53−, Rb−) cells after Cav-1 knockdown using specific shRNA. g The sphere formation in LNCaP Con, LNCAP (p53−, Rb−)-Vc and LNCAP (p53−, Rb−)-shCav1 cells. Scale bar = 100 μm. All data were shown as mean ± SD (n > 10), *P < 0.5, **P < 0.01, ***P < 0.001

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