Fig. 3: Bioinformatic analysis and validation of potentially targeted miRNAs of circRNA-5692 in HCC cells. | Cell Death & Disease

Fig. 3: Bioinformatic analysis and validation of potentially targeted miRNAs of circRNA-5692 in HCC cells.

From: CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

Fig. 3: Bioinformatic analysis and validation of potentially targeted miRNAs of circRNA-5692 in HCC cells.

a The potentially targeted miRNAs of circRNA-5692 were predicted by bioinformatics. b The potential binding sequences of circRNA-5692 to these miRNAs were analyzed by bioinformatics. c Quantitative RT-PCR analysis of the relative RNA levels of the indicated miRNAs in five pairs of HCC tissues. d Quantitative RT-PCR analysis of the relative RNA levels of the indicated miRNAs in the indicated cells. e miR-328-5p overexpression suppressed the circRNA-5692-regulated luciferase activity in HEK293T cells. f circRNA-5692 overexpression decreased miR-328-5p expression in HCC cells. Data are images, or expressed as the mean ± SEM of each group from three separate experiments. ##P < 0.01 vs. CON; ▵▵P < 0.01 vs. circ-OE. OE overexpression, NC transduced with control lentivirus. c cancer tissues, p para-non-tumor tissues.

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