Fig. 6: LINC00518 exerts its prometastasis activity through regulating the AP1S2 levels in vivo. | Cell Death & Disease

Fig. 6: LINC00518 exerts its prometastasis activity through regulating the AP1S2 levels in vivo.

From: Long noncoding RNA LINC00518 acts as a competing endogenous RNA to promote the metastasis of malignant melanoma via miR-204-5p/AP1S2 axis

Fig. 6

a Representative bioluminescence images of mice after tail vein injection of stably expressing lentiviral control or LINC00518 shRNA A375 cells. b The excision lung tissues in nude mice and the number of metastatic lung nodules. c Metastatic lung nodules were confirmed by HE staining. Scale bar, 50 μm. d PCR identified miR-204-5p expression changes. e The expression of LINC00518 and AP1S2 were detected by FISH and immunohistochemistry of sections from the metastatic lung nodules. Scale bar, 25 μm. Data were expressed as the mean ± SD,*P < 0.05, **P < 0.01,

Back to article page