Fig. 5: HEY1 decreases mitochondrial mass and ROS and promotes HCC proliferation. | Cell Death & Disease

Fig. 5: HEY1 decreases mitochondrial mass and ROS and promotes HCC proliferation.

From: Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Fig. 5

a Mitochondrial mass b ROS in Huh7-NTC and shHEY1 subclones exposed to 20 and 1% O2 for 24 h. c Proliferation of Huh7-NTC and shHEY1 subclones exposed to 20 and 1% O2 for 4 days. d HEY1 mRNA expression in MHCC97L-HEY1-OE cells established by CRISPR-dCas9-SAM system. e Mitochondrial mass and f ROS in MHCC97L-EV and –HEY1-OE subclones exposed to 20 and 1% O2 for 24 h. g Cell images of HEY1-OE cells under TEM. Arrows point to mitochondria. Data are presented as mean ± s.d. (Student’s t-test, *P < 0.05, **P < 0.01, ***P < 0.001).

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