Fig. 7: Summary. | Cell Death & Disease

Fig. 7: Summary.

From: Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

Fig. 7

HIF-1 transcriptionally activates HEY1. HEY1 in turn transcriptionally represses PINK1. PINK1 is important to mitochondrial biogenesis. During hypoxia, ROS accumulates at the mitochondria due to inefficient electron transfer through the electron transport chain in the mitochondria, HIF-1 overcomes the oxidative stress through elevating HEY1 to reduce PINK1-mediated mitochondrial biogenesis, making HCC cells less dependent on mitochondria to reduce mitochondrial ROS production. Therefore, the HIF-1/HEY1 pathway confers survival advantages to HCC cells which frequently experience hypoxia.

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