Fig. 8: HP1α inhibition reduces IR-induced DSBs in NBS cells. | Cell Death & Disease

Fig. 8: HP1α inhibition reduces IR-induced DSBs in NBS cells.

From: NBS1 interacts with HP1 to ensure genome integrity

Fig. 8

Analysis of DSB repair kinetics of γH2AX and 53BP1 in mock- and HP1α-silenced MRC5 and NBS cells, irradiated with 1 Gy of X-rays and harvested after 0.5, 3, 6, and 24 h. Graphs express the mean number of either γH2AX or 53BP1 foci/cell derived from the analysis of 100 cells/experimental point, in three independent experiments ±S.D. (t Student’s Test; *p < 0.05, **p < 0.01, ***p < 0.001).

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