Fig. 2: Knockdown of LINC00266-1 suppressed the proliferative ability and induced the apoptosis in OS cells. | Cell Death & Disease

Fig. 2: Knockdown of LINC00266-1 suppressed the proliferative ability and induced the apoptosis in OS cells.

From: LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma

Fig. 2: Knockdown of LINC00266-1 suppressed the proliferative ability and induced the apoptosis in OS cells.The alternative text for this image may have been generated using AI.

a Transfection of sh-LINC00266-1 #1 or sh-LINC00266-1 #2 downregulated LINC00266-1 in MG63 and U2OS cells. b, c CCK-8 assay showed that knockdown of LINC00266-1 reduced the viability in MG63 and U2OS cells. d, e Colony formation assay showed that knockdown of LINC00266-1 reduced the colony formation ability in MG63 and U2OS cells. f Protein levels of Ki67 and PCNA were downregulated in MG63 and U2OS cells with LINC00266-1 knockdown. g, h Flow cytometry showed that knockdown of LINC00266-1 increased the apoptotic rate in MG63 and U2OS cells. i Knockdown of LINC00266-1 downregulated Bid and upregulated Bax in MG63 and U2OS cells. *p < 0.05.

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