Fig. 3: Knockdown of LINC00266-1 reduced the migratory and invasive abilities in OS cells and inhibited the growth of OS in vivo. | Cell Death & Disease

Fig. 3: Knockdown of LINC00266-1 reduced the migratory and invasive abilities in OS cells and inhibited the growth of OS in vivo.

From: LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma

Fig. 3: Knockdown of LINC00266-1 reduced the migratory and invasive abilities in OS cells and inhibited the growth of OS in vivo.The alternative text for this image may have been generated using AI.

a, b Transwell assay showed that knockdown of LINC00266-1 suppressed the migration in MG63 and U2OS cells. c, d Transwell assay showed that knockdown of LINC00266-1 suppressed the invasion in MG63 and U2OS cells. e OS tissues were collected from nude mice 21 days after cell administration. f Mice administered with MG63 cells transfected with sh-LINC00266-1 #1 presented slower tumor growth than control mice. g The tumor weight was lower in mice administered with MG63 cells transfected with sh-LINC00266-1 #1 than in control mice. h The in vivo level of LINC00266-1 decreased in OS tissues harvested from mice administered with MG63 cells transfected with sh-LINC00266-1 #1. i IHC showed lower positive expression of Ki67 in mice administered with MG63 cells transfected with sh-LINC00266-1 #1 than in control mice. *p < 0.05.

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