Fig. 6: Overexpression of SMAD2 abolished the role of LINC00266-1 in OS development.
From: LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma
a, b The proliferation, metastasis and apoptosis in MG63 cells were influenced by LINC00266-1, miR-548c-3p and SMAD2. c Relative levels of Bax, MMP2 and PCNA in MG63 cells were influenced by LINC00266-1, miR-548c-3p and SMAD2. d, e The proliferation, metastasis and apoptosis in U2OS cells were influenced by LINC00266-1, miR-548c-3p and SMAD2. f Relative levels of Bax, MMP2 and PCNA in U2OS cells were influenced by LINC00266-1, miR-548c-3p and SMAD2. g–i The LINC00266-1 level was positively correlated with that of SMAD2 and negatively correlated with that of miR-548c-3p. The SMAD2 level was negatively correlated with that of miR-548c-3p. j–l LINC00266-1 and SMAD2 were favorable to the prognosis in OS, and miR-548c-3p was an unfavorable factor (*p < 0.05. #p < 0.05, compared to sh-LINC00266-1 1# group, &p < 0.05, compared to sh-LINC00266-1 1#+pcDNA-SMAD2 group).
