Fig. 5: p21 deficiency impaired LPS-induced autophagy increase.
From: Autophagy is involved in the protective effect of p21 on LPS-induced cardiac dysfunction
a Representative western blot analysis of proteins involved in inflammation, oxidative stress, and apoptosis (left panel) and average fold change (right panel) in the indicated hearts (n = 6). b Representative transmission electron microscope images of heart tissue. Yellow arrows indicate autophagosomes (n = 6). c Representative western blot analysis of proteins involved in autophagy flux in the indicated hearts of WT and p21KO mice. d Quantization of protein level of LC3II, p62, and Beclin1 in mouse hearts (n = 6). *p < 0.05 versus Ctrl group, #p < 0.05 versus corresponding LPS group.
