Fig. 8: A diagram of the proposed pathway for the cardioprotective of p21.
From: Autophagy is involved in the protective effect of p21 on LPS-induced cardiac dysfunction
LPS induces the expression of p21. p21 binds to LC3B and regulates cardiac autophagy level to attenuate the increase expression of TNFα, MCP1, IL6 as well as damaged mitochondria induced by LPS stimulation, thus protecting the heart.
