Fig. 1: MiR-3622a-3p was identified to be down-regulated in CRC. | Cell Death & Disease

Fig. 1: MiR-3622a-3p was identified to be down-regulated in CRC.

From: MiR-3622a-3p acts as a tumor suppressor in colorectal cancer by reducing stemness features and EMT through targeting spalt-like transcription factor 4

Fig. 1

a The volcano plot of the differentially expressed miRNAs in CRC from TCGA database. b The cluster heat map of the top 20 up-regulated and down-regulated miRNAs in CRC from TCGA database. c The top 10 up-regulated and down-regulated miRNAs in CRC were listed. d MiR-3622a-3p was the most down-regulated miRNA in CRC based on the analysis of TCGA miRNAs-seq data. e MiR-3622a-3p was confirmed to be down-regulated in CRC by qRT-PCR performed on 80 pairs of CRC tissues and adjacent normal tissues. f Overall survival (OS) analysis revealed that high miR-3622a-3p expression was an advantage for CRC patients’ prognosis. All data are from three independent experiments and are presented as the means ± SD (*p < 0.05, **p < 0.01).

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