Fig. 2: Roles of AIMP1 in tumor immunity.
From: Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer
a The absence of AIMP1 in BMDCs reduces Th1 polarization of T cells by impairing p38 MAPK signaling, which significantly impairs BMDC vaccine-mediated protection against melanoma. b AIMP1 activates NK cells through the direct contact between macrophages and NK cells, which inhibits lung metastasis of melanoma cells. Meanwhile, AIMP1 also promotes the secretion of TNF-α by macrophages, which partially supports the activation of NK cells. c AIMP1 inhibits the immunosuppressive activity of MDSCs by attenuating the activation of STATs, Akt, and ERK, thereby suppressing the tumor growth in breast cancer-bearing mice.
