Fig. 4: Roles of AIMP2 in cancer.
From: Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer
Upon DNA damage, AIMP2 is phosphorylated and dissociates from the MSC. Subsequently, the dissociated AIMP2 translocates to the nucleus and directly interacts with tumor suppressor p53. AIMP2 promotes the pro-apoptotic activity of TNF-α via ubiquitin-mediated degradation of TRAF2. AIMP2 disrupts the interaction between AXIN and DVL1 by binding to DVL1, which inhibits Wnt/β-catenin signaling and therefore controls ISC compartments and tumorigenesis. Furthermore, the dissociated AIMP2 binds to Smurf2, thereby enhancing the ubiquitination of FBP and inhibiting tumorigenesis.
