Fig. 5: Roles of AIMP3 in cancer.
From: Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer
Under UV irradiation, MRS is phosphorylated at Ser662 by GCN2, causing a conformational change in MRS and the subsequent dissociation of AIMP3 from MRS. The dissociated AIMP3 translocates to the nucleus and upregulates p53 by directly interacting with the FAT domains of ATM/ATR, thereby responding to DNA damage.
