Fig. 1: Hypoxic CRC cells possess higher metastatic capacity than normoxic CRC cells. | Cell Death & Disease

Fig. 1: Hypoxic CRC cells possess higher metastatic capacity than normoxic CRC cells.

From: Hypoxic colorectal cancer cells promote metastasis of normoxic cancer cells depending on IL-8/p65 signaling pathway

Fig. 1: Hypoxic CRC cells possess higher metastatic capacity than normoxic CRC cells.The alternative text for this image may have been generated using AI.

a Schematic of the in vitro physical hypoxic treatment of CRC cells. b Immunoblot analysis of HIF1α in hypoxic CRC cells. Normoxic CRC cells as control, and β-actin for loading control. c Transwell invasion assays. In all, 4 × 104 hypoxic (HSS) and normoxic (Control) CRC cells were incubated, invaded cells were quantified. Scale bars: 200 µm. Mean ± SD from triple experiments. *P < 0.05, **P < 0.01. d Quantified numbers of visible metastases in NOD/SCID mice by injecting hypoxic (HSS) and normoxic (Control) xhCRC cells to tail veins (n = 5 per group). Data are presented as mean ± SD. ***P < 0.001.

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