Fig. 1: T3 treatment rescued histological and functional deficits after TBI.
From: Dual effects of thyroid hormone on neurons and neurogenesis in traumatic brain injury
a, b Representative images (a, arrow) and quantification (b) of cortical lesion volume (n = 5, **P < 0.01). c Analysis of water content (n = 5, *P < 0.05). d–g Morris water maze (MWM). Graph showing hidden platform trial (d) and visible platform trials (e). Representative images (f) and quantification of probe tests (g, #P > 0.05, *P < 0.05). h–k Elevated plus maze. In the open arm, T3-treated TBI mice had similar performance to sham in the present time (h), but vehicle-treated TBI mice spent more time (h, *P < 0.05). i Velocity in the open arm (#P > 0.05). j, k All groups had similar velocity in the closed arm (j, #P > 0.05) and traveled similar total distance (k, #P > 0.05). l Novel object recognition (NOR, **P < 0.01). m Neurological severity score (NSS, **P < 0.01, ***P < 0.001 between T3- and vehicle-treated TBI mice). Sham mice, n = 20; T3-treated sham mice, n = 20; vehicle-treated TBI mice, n = 20; T3-treated TBI mice, n = 22. All data are mean ± SD. V vehicle.
