Fig. 5: TRPA1/NOX1 pathway is implicated in retinal damage.
From: TRPA1 mediates damage of the retina induced by ischemia and reperfusion in mice
a, b Representative images and mean gray value of 4-HNE staining in GCL and INL in retina from C57BL/6J mice after at a day-2 and b day-7 after ischemia and reperfusion (I/R) and treated daily with eye drops (5 µl, 10 mM) ML171 or its vehicle (Veh). c, d Representative images of hematoxylin and eosin staining, retinal thickness and total number of cells in the GCL in retina from C57BL/6J mice at c day-2 and d day-7 after I/R and treated daily with eye drops (5 µl, 10 mM) ML171 or its Veh. Representative images and total number of RBMPS+ cells in retina from C57BL/6J mice at e day-2 and f day-7 after I/R and treated daily with eye drops (5 µl, 10 mM) ML171 or its Veh. Control (CTL) indicates mice receiving all the procedures except I/R. Scale bars: 20 µm (a, b), 50 µm (c–f). Data are expressed as the percentage difference (Δ%) from CTL, and displayed as mean ± SEM, n = 4 to 5 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001 between indicated groups; two-way ANOVA and Bonferroni post hoc test.
