Fig. 7: The proposed mechanisms of hederagenin-inhibited autophagy and the synergistic effects of hederagenin and chemotherapeutic agents. | Cell Death & Disease

Fig. 7: The proposed mechanisms of hederagenin-inhibited autophagy and the synergistic effects of hederagenin and chemotherapeutic agents.

From: Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells

Fig. 7

Hederagenin acted as a novel late-phase autophagy inhibitor by targeting lysosomes, and that hederagenin may synergize the cytotoxicity effects of cisplatin and paclitaxel by blocking the cell death preventive autophagy and amplifying cytotoxic ROS.

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