Fig. 4: MICAL2 characterization in muscle fibers. | Cell Death & Disease

Fig. 4: MICAL2 characterization in muscle fibers.

From: MICAL2 is essential for myogenic lineage commitment

Fig. 4: MICAL2 characterization in muscle fibers.The alternative text for this image may have been generated using AI.

a Upper panels show IF analysis for LAMININ (red) and MICAL2 (green) localization on TA cross-sections of uninjured control C57/Bl6 (C57), acute regeneration of C57/Bl6 after cardiotoxin injection (C57 CTX), chronic regeneration of β-SGnull and mdx dystrophic models. Nuclei stained with HOECHST (blue). Magnification 20x. Scale bars 50 μm. b Upper panels show average CSA between mature and regenerating fibers of C57 CTX, β-SGnull and mdx dystrophic models. Lower panels show MICAL2 fluorescence intensity calculated as absolute intensity (MICAL2 AI) in mature and central nucleated regenerating fibers of C57 CTX, β-SGnull and mdx dystrophic models. N = 5. c WB and relative quantification for MICAL2 on gastrocnemius of uninjured control C57/Bl6 (C57) and chronic regeneration of β-SGnull and mdx dystrophic models. N = 3. * = p < 0.05; **** = p < 0.0001 by one-way ANOVA test.

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