Fig. 8: A proposed mechanism for UCHL1 to regulate foam cell formation via stabilizing the protein expression of CD36.
From: Deubiquitination of CD36 by UCHL1 promotes foam cell formation
OxLDL is uptaked by macrophages via scavenger receptor CD36 which locates in cell membrane, resulting in foam cell formation. UCHL1, as a deubiquitinating enzyme, blocks the ubiquitination progress of CD36 protein and then inhibiting its degradation. The stabilization of CD36 controlled by UCHL1 promoted foam cell formation in macrophages.
