Fig. 8: Hoxaas3 contributes to PF by regulating the Runx1. | Cell Death & Disease

Fig. 8: Hoxaas3 contributes to PF by regulating the Runx1.

From: LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1

Fig. 8

a, b qPCR and western blot analysis of Runx1 mRNA (a) and protein (b) level in the lungs of BLM-treated mice with Hoxaas3 inhibition (n = 6). (c–e) qPCR analysis of mRNA levels of collagen 1a1 (c), collagen 3a1 (d) and Fibronectin (e) (n = 3). f Western blot analysis of expression of Fibronectin, Vimentin, a-SMA, and Runx1 (n = 3). g Schematic diagram of the molecular mechanisms underlying the TGF-β1/Smad4-Hoxaas3–miR-450b-5p–Runx1 axis-mediated regulation of lung fibrosis (n = 3). (All data are presented as mean ± SD, *P < 0.05).

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