Fig. 5: HHT bound to EphB4 and suppressed its expression. | Cell Death & Disease

Fig. 5: HHT bound to EphB4 and suppressed its expression.

From: Homoharringtonine suppresses tumor proliferation and migration by regulating EphB4-mediated β-catenin loss in hepatocellular carcinoma

Fig. 5: HHT bound to EphB4 and suppressed its expression.

a Western blot analysis of HepG2 cells EphB4 expression after HHT treatment. b Western blot analysis of EphB4 expression in HepG2 cells treated with HHT or/and EphrinB2 Fc. c Immunochemistry analysis of EphB4 expression in HepG2 tumors after HHT treatment (n = 5). ×400 magnification. d RT-PCR analysis of HepG2 cells EphB4 expression after HHT treatment (n = 5). All data represent mean ± SEM. *p < 0.05 compared to vehicle controls. e Western blot analysis of HepG2 cells EphB4 expression after HHT, NVP-BHG712, or both treatments. f Molecular docking analysis of the EphB4 protein and HHT.

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