Fig. 1: CRS promotes metastasis of SK-OV-3 ovarian cancer cells in nude mouse models. | Cell Death & Disease

Fig. 1: CRS promotes metastasis of SK-OV-3 ovarian cancer cells in nude mouse models.

From: Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

Fig. 1

a The schematic graph of establishing chronic restraint stress (CRS) animal models in this study. b ELISA was used to evaluate the effects of CRS on nude mice by examining the concentration of serum corticosterone (n = 6). c Gross morphology of the abdominally implanted tumor burden of ovarian cancer cells in nude mice. Quantification of abdominal tumor nodules (d) and tumor weights (e) of the control group and the CRS group (n = 6). f Representative images of H&E staining (i, ii), IF staining detecting EMT-related transcription factors, including TWIST (iii, iv), SLUG (v, vi), SNAIL (vii, viii), and β-catenin (ix, x) in tumor tissues obtained from nude mouse models. *P < 0.05; ***P < 0.001. Scale bar, 100 μM.

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